OTOA

Across TCGA pan-cancer cohorts, OTOA RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of OTOA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OTOA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OTOA is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where OTOA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTOA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.386	<.001	12	view →
COAD	All	All	−0.097	<.001	10	view →
KIRP	Male	All	+0.683	<.001	9	view →
KICH	All	All	+0.184	<.001	7	view →
THCA	All	All	+0.073	<.001	7	view →
LUSC	Male	II,III,IV	−0.299	<.001	5	view →
HNSC	All	III,IV	+0.059	.007	4	view →
STAD	All	All	+0.086	.017	3	view →
PAAD	All	All	−0.500	.011	2	view →
CHOL	All	II,III,IV	−0.114	.044	2	view →
UCEC	All	All	+0.083	.006	2	view →
LIHC	All	II,III,IV	+0.071	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

OTOA–KIRC

Open the KIRC breakdown →