OTOA

Across TCGA patient cohorts, OTOA RNA expression is significantly associated with the protein abundance of many other proteins, with 8,309 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible OTOA-associated proteins across cancer lineages are PYCR1, SLIRP, and IQGAP2_S16. Each is linked with OTOA in more than 4 cancer types. Because this analysis shows association rather than direction, both OTOA-to-partner and partner-to-OTOA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OTOA versus PYCR1 in LUAD, with a Pearson correlation of -0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOA→partner) and Y-score (partner→OTOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PYCR1 →	-0.533	-0.127	.002	.002	3	4
LUAD	SLIRP →	-0.432	-0.137	<.001	.001	3	4
LUAD	IQGAP2_S16 →	+0.885	+0.168	<.001	<.001	3	4
LUAD	LRPPRC →	-0.440	-0.126	<.001	.001	3	4
LUAD	TBCK →	+0.183	+0.145	<.001	<.001	3	4
OV	FKBP15 →	+0.280	+0.085	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,309 associations by consensus.

OTOA vs PYCR1 — LUAD

Explore this scatter interactively →