OTOA

Across TCGA patient cohorts, OTOA mutation is significantly associated with the RNA expression of many other genes, with 3,869 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOA-associated genes across cancer lineages are XRCC2, CEP72, and TICRR. Each is linked with OTOA in more than 3 cancer types. Because this analysis shows association rather than direction, both OTOA-to-partner and partner-to-OTOA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XRCC2 grouped by OTOA-low versus OTOA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOA→partner) and Y-score (partner→OTOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XRCC2 →	+0.590	+2.425	<.001	.001	3	4
UCEC	CEP72 →	+0.543	+2.364	<.001	<.001	3	4
UCEC	TICRR →	+0.615	+1.716	<.001	.004	3	4
LIHC	RPSAP27 →	+0.063	+5.647	<.001	.004	3	3
SKCM	TERT →	+0.389	+2.315	.008	<.001	3	3
UCEC	SAAL1 →	+0.475	+3.595	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,869 associations by consensus.

XRCC2 by OTOA expression — UCEC

Explore this box plot interactively →