OTOA

Across TCGA patient cohorts, OTOA mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOA-associated genes across cancer lineages are JNK_pT183_Y185, STAT5a, and ATM. Each is linked with OTOA in more than 2 cancer types. Because this analysis shows association rather than direction, both OTOA-to-partner and partner-to-OTOA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by OTOA-low versus OTOA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOA→partner) and Y-score (partner→OTOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.188	-2.807	.001	.003	3	3
UCEC	STAT5a →	+0.301	+1.362	.033	.037	3	3
UCEC	ATM →	-0.626	-3.794	<.001	<.001	3	3
LUSC	Ku80 →	+0.357	+3.000	.034	.035	3	2
UCEC	eIF4E →	+0.158	+1.662	.034	.011	3	2
UCEC	JNK2 →	+0.304	+2.874	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

JNK_pT183_Y185 by OTOA expression — UCEC

Explore this box plot interactively →