OTOA

Across TCGA cell cohorts, OTOA RNA expression is significantly associated with the go_rna of many other GO terms, with 728 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OTOA-associated GO terms across cancer lineages are Reproductive system development, Immature B cell differentiation, and Apical protein localization. Each is linked with OTOA in more than 4 cancer types. Because this analysis shows association rather than direction, both OTOA-to-partner and partner-to-OTOA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Reproductive system development grouped by OTOA-low versus OTOA-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOA→partner) and Y-score (partner→OTOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Reproductive system development →	-0.034	-0.235	.005	.008	3	5
CNS	Immature B cell differentiation →	+0.095	+0.043	.002	.002	3	4
CNS	Apical protein localization →	-0.095	-0.092	.003	.003	3	4
CNS	Replicative senescence →	+0.113	+0.057	<.001	.009	3	4
BLOOD_Leukemia	Antigen processing and presentation of endogenous antigen →	+0.153	+0.365	<.001	.002	3	4
BLOOD_Leukemia	Reproductive structure development →	-0.033	-0.233	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 728 associations by consensus.

Reproductive system development by OTOA expression — BLOOD_Leukemia

Explore this box plot interactively →