OTOA

Across TCGA cell cohorts, OTOA mutation is significantly associated with the drug of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTOA-associated genes across cancer lineages are PRT062607, TAF1_5496, and Quizartinib. Each is linked with OTOA in more than 1 cancer types. Because this analysis shows association rather than direction, both OTOA-to-partner and partner-to-OTOA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRT062607 grouped by OTOA-low versus OTOA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOA→partner) and Y-score (partner→OTOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRT062607 →	+0.698	+2.991	.002	.018	3	1
LARGE_INTESTINE	TAF1_5496 →	+0.674	+3.000	.001	.017	3	1
LARGE_INTESTINE	Quizartinib →	+0.473	+2.874	.001	.021	3	1
LARGE_INTESTINE	Cytarabine →	+1.003	+2.655	.008	.044	2	1
LARGE_INTESTINE	LCL161 →	+0.404	+2.868	.008	.022	2	1
LARGE_INTESTINE	IWP-2 →	+0.268	+3.115	.033	.015	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PRT062607 by OTOA expression — LARGE_INTESTINE

Explore this box plot interactively →