Q-omics provides the consensus-scored OSTN profile across patient tissues and cancer cell-line models. OSTN expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, OSTN is differentially expressed in 12, with the highest sampling consensus in THCA. Additionally, OSTN RNA expression shows 10,980 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight UCEC, THCA, and TGCT as cancer lineages where OSTN shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OSTN — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OSTN survival associations across molecular data types. OSTN RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OSTN RNA expression–survival associations across cancer types. High OSTN expression shows unfavorable associations in UCEC, ACC, CESC and KIRP, but favorable associations in CHOL and SKCM. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for OSTN RNA expression.
This table summarizes OSTN tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for OSTN. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OSTN shows lower tumor expression in THCA, LUAD, KICH, BLCA, HNSC and COAD. The THCA box plot shows higher OSTN RNA expression in normal versus tumor tissue (log2 FC = −0.353, t-test p < 0.001).
This table shows molecular features associated with OSTN in patient tissues and cancer cell lines. In patient samples, OSTN shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, OSTN RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and BONE.
