OSTN-AS1

Across TCGA pan-cancer cohorts, OSTN-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated OSTN-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OSTN-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated OSTN-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and LUAD are the cancer types where OSTN-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.764	0.657	.004	56	view →
BRCA	DFS	Tertile	All	0.546	0.484	.006	52	view →
LUAD	DFS	Tertile	All	0.751	0.620	.002	51	view →
SKCM	OS	Quartile	All	0.446	0.247	<.001	44	view →
KIRC	OS	Median	All	0.554	0.700	<.001	38	view →
GBM	DFS	Quartile	All	0.160	0.317	.005	29	view →
ESCA	DFS	Quartile	II,III,IV	0.509	0.247	.014	17	view →
PAAD	DFS	Quartile	II,III,IV	0.667	0.352	.003	14	view →
PRAD	DFS	Quartile	All	0.890	0.952	.007	14	view →
ACC	OS	Quartile	II,III,IV	0.310	0.728	.011	14	view →
MESO	OS	Quartile	III,IV	0.609	0.386	.014	9	view →
SARC	OS	Median	All	0.860	0.676	.004	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

OSTN-AS1–HNSC (DFS)

Open the HNSC breakdown →