OSTN-AS1

Across TCGA pan-cancer cohorts, OSTN-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of OSTN-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where OSTN-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types OSTN-AS1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and UCEC are the cancer types where OSTN-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OSTN-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.882	<.001	11	view →
KICH	Female	II,III,IV	−0.760	<.001	11	view →
UCEC	All	All	−0.455	.011	6	view →
LUAD	All	All	+0.293	.002	4	view →
STAD	Female	III,IV	+1.645	.006	3	view →
CHOL	All	All	−1.014	.012	2	view →
KIRP	Female	II,III,IV	−0.439	.032	2	view →
LUSC	Female	All	−0.362	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

OSTN-AS1–COAD

Open the COAD breakdown →