OSTM1

Across TCGA patient cohorts, OSTM1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSTM1-associated genes across cancer lineages are NCF4, RAC2, and STX11. Each is linked with OSTM1 in more than 5 cancer types. Because this analysis shows association rather than direction, both OSTM1-to-partner and partner-to-OSTM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OSTM1 versus NCF4 in LSCC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSTM1→partner) and Y-score (partner→OSTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NCF4 →	+0.792	+0.260	<.001	.002	3	5
OV	RAC2 →	+1.046	+0.386	.004	.001	3	5
BRCA	STX11 →	+0.528	+0.348	.005	.005	2	6
GBM	CHD8 →	-0.420	-0.339	<.001	<.001	3	5
LSCC	SUPT16H →	-0.534	-0.218	<.001	.002	3	5
COAD	CTSZ →	+0.718	+0.512	.002	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,120 associations by consensus.

OSTM1 vs NCF4 — LSCC

Explore this scatter interactively →