OSMR

Across TCGA pan-cancer cohorts, OSMR mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of OSMR’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where OSMR mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types OSMR is over-expressed in tumor.

CCRCC, LUAD, and HNSC are the cancer types where OSMR tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OSMR mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	II,III,IV	+1.192	<.001	11	view →
LUAD	All	III,IV	+0.417	<.001	8	view →
HNSC	Male	III,IV	+0.443	<.001	6	view →
LSCC	Female	All	+0.382	<.001	5	view →
PDAC	All	All	+0.445	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

OSMR–CCRCC

Open the CCRCC breakdown →