OSMR

Across TCGA pan-cancer cohorts, OSMR RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated OSMR data layer compared with 9 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher OSMR RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OSMR expression acts as an unfavorable survival marker, although some lineages such as LAML and PRAD show a favorable association.

KIRP, OV, and LGG are the cancer types where OSMR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.642	0.857	.001	62	view →
OV	OS	Tertile	III,IV	0.265	0.399	.001	62	view →
LGG	OS	Median	All	0.348	0.567	<.001	54	view →
PAAD	DFS	Tertile	All	0.162	0.430	.002	43	view →
STAD	OS	Quartile	II,III,IV	0.534	0.879	.005	41	view →
GBM	DFS	Median	All	0.193	0.319	<.001	36	view →
BLCA	DFS	Quartile	All	0.221	0.507	.007	34	view →
CESC	DFS	Median	III,IV	0.225	0.741	.009	34	view →
ACC	DFS	Quartile	II,III,IV	0.127	0.738	.001	34	view →
LAML	DFS	Tertile	All	0.477	0.219	.004	24	view →
UVM	DFS	Quartile	III,IV	0.106	1.000	.010	23	view →
MESO	DFS	Median	II,III,IV	0.234	0.667	.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

OSMR–KIRP (DFS)

Open the KIRP breakdown →