OSMR

Across TCGA patient cohorts, OSMR mutation is significantly associated with the RNA expression of many other genes, with 3,698 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSMR-associated genes across cancer lineages are LINC01909, RNY3, and CENPU. Each is linked with OSMR in more than 3 cancer types. Because this analysis shows association rather than direction, both OSMR-to-partner and partner-to-OSMR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01909 grouped by OSMR-low versus OSMR-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSMR→partner) and Y-score (partner→OSMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC01909 →	+0.454	+2.611	<.001	.005	3	4
COAD	RNY3 →	+0.819	+2.679	<.001	.001	3	3
UCEC	CENPU →	+0.487	+1.479	.003	.001	3	3
COAD	CATSPER3 →	+0.398	+2.100	<.001	.003	3	3
UCEC	EME1 →	+0.482	+2.627	<.001	<.001	3	3
UCEC	MPV17L →	-0.651	-2.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,698 associations by consensus.

LINC01909 by OSMR expression — COAD

Explore this box plot interactively →