OSMR

Across TCGA patient cohorts, OSMR mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSMR-associated genes across cancer lineages are p90 RSK, eIF4E, and PCNA. Each is linked with OSMR in more than 1 cancer types. Because this analysis shows association rather than direction, both OSMR-to-partner and partner-to-OSMR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by OSMR-low versus OSMR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSMR→partner) and Y-score (partner→OSMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p90 RSK →	+0.142	+1.362	.015	.028	3	2
UCEC	eIF4E →	+0.149	+2.598	.016	<.001	3	2
UCEC	PCNA →	+0.135	+1.807	.034	.024	3	2
UCEC	ATM →	-0.539	-2.489	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.410	+1.300	.019	.034	3	2
COAD	MIG-6 →	+0.081	+2.059	.020	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p90 RSK by OSMR expression — SKCM

Explore this box plot interactively →