OSMR

Across TCGA cell cohorts, OSMR RNA expression is significantly associated with the go_rna of many other GO terms, with 5,434 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible OSMR-associated GO terms across cancer lineages are Oncostatin-M-mediated signaling pathway, Positive regulation of cell-substrate adhesion, and Regulation of proteolysis. Each is linked with OSMR in more than 15 cancer types. Because this analysis shows association rather than direction, both OSMR-to-partner and partner-to-OSMR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oncostatin-M-mediated signaling pathway grouped by OSMR-low versus OSMR-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OSMR→partner) and Y-score (partner→OSMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Oncostatin-M-mediated signaling pathway →	+0.362	+3.590	<.001	<.001	3	16
SKIN	Positive regulation of cell-substrate adhesion →	+0.124	+2.865	<.001	<.001	3	14
BONE	Regulation of proteolysis →	+0.127	+2.072	<.001	.003	3	14
LIVER	Wound healing →	+0.110	+1.867	.001	.004	3	14
BONE	Chaperone-mediated autophagy →	+0.181	+2.699	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Positive regulation of acute inflammatory response →	+0.410	+2.742	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,434 associations by consensus.

Oncostatin-M-mediated signaling pathway by OSMR expression — BONE

Explore this box plot interactively →