OSMR

Across TCGA cell cohorts, OSMR mutation is significantly associated with the RNA expression of many other genes, with 699 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSMR-associated genes across cancer lineages are OR6V1, IFNL4, and DESI1. Each is linked with OSMR in more than 1 cancer types. Because this analysis shows association rather than direction, both OSMR-to-partner and partner-to-OSMR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6V1 grouped by OSMR-low versus OSMR-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSMR→partner) and Y-score (partner→OSMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR6V1 →	+0.026	+3.204	<.001	<.001	3	2
SKIN	IFNL4 →	+0.039	+3.204	<.001	<.001	3	2
LARGE_INTESTINE	DESI1 →	+0.550	+3.321	<.001	.003	3	2
LARGE_INTESTINE	RANGRF →	+0.515	+3.800	.007	<.001	3	2
LARGE_INTESTINE	NDUFC1 →	+0.699	+2.502	<.001	.005	3	2
LARGE_INTESTINE	EXOSC9 →	+0.639	+2.502	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 699 associations by consensus.

OR6V1 by OSMR expression — SKIN

Explore this box plot interactively →