OSMR-AS1

Across TCGA pan-cancer cohorts, OSMR-AS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated OSMR-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher OSMR-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OSMR-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and UCS show a favorable association.

ACC, KIRP, and LGG are the cancer types where OSMR-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Quartile	All	0.184	0.719	<.001	80	view →
KIRP	DFS	Quartile	All	0.509	0.774	<.001	73	view →
LGG	OS	Median	All	0.713	0.903	<.001	54	view →
MESO	OS	Tertile	IV	0.917	0.284	.002	50	view →
GBM	DFS	Median	All	0.194	0.319	<.001	45	view →
STAD	DFS	Quartile	All	0.209	0.412	.011	27	view →
HNSC	DFS	Tertile	II,III,IV	0.197	0.520	.003	27	view →
COAD	DFS	Median	II,III,IV	0.664	0.805	.003	26	view →
THCA	DFS	Median	III,IV	0.756	0.938	.002	25	view →
UCS	DFS	Median	All	0.639	0.397	.013	24	view →
KIRC	DFS	Quartile	All	0.531	0.679	.005	20	view →
SKCM	OS	Median	III,IV	0.835	0.595	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

OSMR-AS1–ACC (DFS)

Open the ACC breakdown →