OSMR-AS1

Across TCGA pan-cancer cohorts, OSMR-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of OSMR-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OSMR-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OSMR-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where OSMR-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OSMR-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.515	<.001	11	view →
KIRC	Male	All	+0.350	<.001	9	view →
KICH	Female	II,III,IV	−1.051	<.001	8	view →
LUSC	Male	All	+0.400	.001	3	view →
THCA	All	All	−0.198	<.001	3	view →
LIHC	All	All	+0.164	.001	3	view →
BLCA	Male	IV	−0.527	.004	2	view →
KIRP	All	II,III,IV	+0.361	.036	2	view →
UCEC	All	All	−0.356	.004	2	view →
LUSC	Male	III,IV	−0.714	.048	1	view →
CHOL	All	All	+0.585	.007	1	view →
ESCA	All	All	+0.403	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

OSMR-AS1–HNSC

Open the HNSC breakdown →