OSGIN2

Across TCGA cell cohorts, OSGIN2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OSGIN2-associated genes across cancer lineages are C14orf177, FAM47C, and LGALS14. Each is linked with OSGIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSGIN2-to-partner and partner-to-OSGIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf177 grouped by OSGIN2-low versus OSGIN2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSGIN2→partner) and Y-score (partner→OSGIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C14orf177 →	+0.020	+6.022	<.001	.001	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
SKIN	LGALS14 →	+0.032	+5.415	<.001	.004	3	1
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.036	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IL22 →	+0.037	+5.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

C14orf177 by OSGIN2 expression — SKIN

Explore this box plot interactively →