OSGEP

Across TCGA patient cohorts, OSGEP mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSGEP-associated genes across cancer lineages are ATM, BRCA2, and Chk2. Each is linked with OSGEP in more than 1 cancer types. Because this analysis shows association rather than direction, both OSGEP-to-partner and partner-to-OSGEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by OSGEP-low versus OSGEP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSGEP→partner) and Y-score (partner→OSGEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.438	-2.986	.027	.035	3	1
UCEC	BRCA2 →	-0.130	-1.992	.022	.031	3	1
UCEC	Chk2 →	-0.219	-3.169	.032	.019	3	1
UCEC	PTEN →	-0.348	-2.115	.045	.019	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ATM by OSGEP expression — UCEC

Explore this box plot interactively →