OSCP1

Across TCGA patient cohorts, OSCP1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSCP1-associated genes across cancer lineages are Ku80, N-Cadherin, and c-Met_pY1235. Each is linked with OSCP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSCP1-to-partner and partner-to-OSCP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by OSCP1-low versus OSCP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSCP1→partner) and Y-score (partner→OSCP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.331	+3.335	.007	.005	3	1
UCEC	N-Cadherin →	+0.252	+2.817	.023	.036	3	1
UCEC	c-Met_pY1235 →	+0.139	+3.321	<.001	.010	1	2
UCEC	INPP4B →	-0.536	-3.308	.001	.010	1	1
UCEC	mTOR_pS2448 →	-0.176	-3.321	.024	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Ku80 by OSCP1 expression — UCEC

Explore this box plot interactively →