OSBPL8

Across TCGA pan-cancer cohorts, OSBPL8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OSBPL8 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OSBPL8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OSBPL8 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where OSBPL8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.473	0.769	<.001	57	view →
LSCC	DFS	Median	All	1.000	0.878	<.001	45	view →
LUAD	DFS	Median	III,IV	0.778	0.341	.017	8	view →
GBM	DFS	Quartile	All	0.470	0.274	.025	6	view →
UCEC	DFS	Median	III,IV	0.889	0.460	.044	4	view →
CCRCC	DFS	Tertile	II,III,IV	0.912	0.769	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OSBPL8–HNSC (DFS)

Open the HNSC breakdown →