OSBPL8

Across TCGA patient cohorts, OSBPL8 mutation is significantly associated with the RNA expression of many other genes, with 3,494 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL8-associated genes across cancer lineages are MTATP6P21, RN7SL354P, and LINC01047. Each is linked with OSBPL8 in more than 2 cancer types. Because this analysis shows association rather than direction, both OSBPL8-to-partner and partner-to-OSBPL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTATP6P21 grouped by OSBPL8-low versus OSBPL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL8→partner) and Y-score (partner→OSBPL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTATP6P21 →	+0.166	+1.382	<.001	.009	3	3
UCEC	RN7SL354P →	+0.117	+1.319	.006	.006	3	3
BLCA	LINC01047 →	+0.050	+3.413	.002	.001	3	3
BRCA	FAM74A6 →	+0.045	+6.324	<.001	.001	3	2
BRCA	MIR4669 →	+0.793	+5.575	<.001	.004	3	2
PAAD	ECM1P2 →	+0.027	+5.213	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,494 associations by consensus.

MTATP6P21 by OSBPL8 expression — UCEC

Explore this box plot interactively →