OSBPL8

Across TCGA patient cohorts, OSBPL8 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL8-associated genes across cancer lineages are Notch1, 4E-BP1_pS65, and Caspase-8. Each is linked with OSBPL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBPL8-to-partner and partner-to-OSBPL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by OSBPL8-low versus OSBPL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL8→partner) and Y-score (partner→OSBPL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.168	+1.584	<.001	.005	3	2
UCEC	4E-BP1_pS65 →	-0.127	-2.222	.039	.009	3	2
UCEC	Caspase-8 →	-0.229	-2.111	.003	<.001	3	2
UCEC	14-3-3_beta →	-0.070	-1.780	.025	.024	3	1
UCEC	eIF4E →	+0.152	+2.713	.021	.003	3	1
UCEC	eIF4G →	+0.207	+1.137	.034	.041	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Notch1 by OSBPL8 expression — UCEC

Explore this box plot interactively →