OSBPL8

Across TCGA cell cohorts, OSBPL8 mutation is significantly associated with the RNA expression of many other genes, with 176 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSBPL8-associated genes across cancer lineages are GPR119, SPPL2C, and REG3G. Each is linked with OSBPL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBPL8-to-partner and partner-to-OSBPL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR119 grouped by OSBPL8-low versus OSBPL8-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL8→partner) and Y-score (partner→OSBPL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR119 →	+0.040	+4.906	<.001	.006	3	1
OESOPHAGUS	SPPL2C →	+0.033	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CST5 →	+0.532	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MROH2B →	+0.116	+5.643	<.001	.002	3	1
BREAST	TARM1 →	+0.022	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 176 associations by consensus.

GPR119 by OSBPL8 expression — OESOPHAGUS

Explore this box plot interactively →