OSBPL7

Across TCGA pan-cancer cohorts, OSBPL7 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OSBPL7 data layer compared with 19 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher OSBPL7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OSBPL7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where OSBPL7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.493	0.916	.001	54	view →
HNSC	DFS	Median	IV	0.925	0.716	.011	12	view →
PDAC	DFS	Median	II,III,IV	0.829	0.619	.015	8	view →
LUAD	DFS	Tertile	II,III,IV	1.000	0.765	.033	4	view →
CCRCC	DFS	Tertile	All	0.900	0.697	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OSBPL7–LSCC (DFS)

Open the LSCC breakdown →