OSBPL7

Across TCGA pan-cancer cohorts, OSBPL7 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of OSBPL7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where OSBPL7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OSBPL7 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KIRP, KICH, and LIHC are the cancer types where OSBPL7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OSBPL7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	+0.688	<.001	9	view →
KICH	Male	All	−1.023	<.001	8	view →
LIHC	Female	II,III,IV	+0.809	<.001	6	view →
COAD	Female	All	−0.535	.001	4	view →
CHOL	Female	All	+2.670	<.001	3	view →
LUSC	Male	All	−0.523	<.001	3	view →
STAD	Male	IV	−1.235	.008	2	view →
READ	Male	All	−0.966	.003	2	view →
STAD	Male	All	+0.880	.018	2	view →
UCEC	All	All	−0.604	<.001	2	view →
KIRC	All	All	+0.209	.008	2	view →
LUAD	All	All	+0.282	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

OSBPL7–KIRP

Open the KIRP breakdown →