OSBPL7

Across TCGA patient cohorts, OSBPL7 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL7-associated genes across cancer lineages are MEK1, eIF4E, and eEF2. Each is linked with OSBPL7 in more than 3 cancer types. Because this analysis shows association rather than direction, both OSBPL7-to-partner and partner-to-OSBPL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by OSBPL7-low versus OSBPL7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL7→partner) and Y-score (partner→OSBPL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.380	+2.321	.003	.005	3	4
UCEC	eIF4E →	+0.211	+1.925	.005	.005	3	3
UCEC	eEF2 →	+0.388	+2.700	.002	.005	3	2
COAD	INPP4B →	-0.530	-3.161	.003	.019	3	2
COAD	ASNS →	+0.748	+3.178	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.280	-2.321	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

MEK1 by OSBPL7 expression — UCEC

Explore this box plot interactively →