OSBPL7

Across TCGA cell cohorts, OSBPL7 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible OSBPL7-associated genes across cancer lineages are PDE6C, SAXO1, and ACER1. Each is linked with OSBPL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBPL7-to-partner and partner-to-OSBPL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE6C grouped by OSBPL7-low versus OSBPL7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL7→partner) and Y-score (partner→OSBPL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDE6C →	+0.246	+3.273	.001	.006	3	2
LARGE_INTESTINE	SAXO1 →	+0.042	+3.819	.001	.001	3	1
LARGE_INTESTINE	ACER1 →	+0.075	+3.145	.002	.004	3	1
LARGE_INTESTINE	ASCL3 →	+0.141	+2.989	.001	.003	3	1
LARGE_INTESTINE	TAT →	+0.107	+3.254	.001	.007	3	1
STOMACH	TRIM49B →	+0.008	+3.209	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PDE6C by OSBPL7 expression — LARGE_INTESTINE

Explore this box plot interactively →