OSBPL6

Across TCGA patient cohorts, OSBPL6 mutation is significantly associated with the RNA expression of many other genes, with 5,246 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL6-associated genes across cancer lineages are SOD1, NDUFA6, and DCK. Each is linked with OSBPL6 in more than 4 cancer types. Because this analysis shows association rather than direction, both OSBPL6-to-partner and partner-to-OSBPL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOD1 grouped by OSBPL6-low versus OSBPL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL6→partner) and Y-score (partner→OSBPL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SOD1 →	+0.236	+1.601	.009	.005	3	5
UCEC	NDUFA6 →	+0.539	+2.403	<.001	<.001	3	5
UCEC	DCK →	+0.547	+1.807	<.001	<.001	3	4
UCEC	H2AZ1 →	+0.778	+2.906	<.001	<.001	3	4
UCEC	MTHFD2 →	+0.607	+1.909	<.001	<.001	3	4
UCEC	UQCRC1 →	+0.438	+2.251	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,246 associations by consensus.

SOD1 by OSBPL6 expression — UCEC

Explore this box plot interactively →