OSBPL6

Across TCGA pan-cancer cohorts, OSBPL6 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated OSBPL6 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher OSBPL6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OSBPL6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

UVM, MESO, and BLCA are the cancer types where OSBPL6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.384	0.775	<.001	139	view →
MESO	OS	Median	All	0.420	0.663	<.001	132	view →
BLCA	OS	Median	All	0.319	0.542	<.001	120	view →
KICH	DFS	Median	III,IV	0.172	1.000	<.001	107	view →
ACC	DFS	Tertile	All	0.293	0.769	<.001	81	view →
KIRP	OS	Median	II,III,IV	0.728	0.905	.005	51	view →
THCA	OS	Median	II,III,IV	0.927	1.000	.006	42	view →
LGG	OS	Median	All	0.858	0.931	<.001	36	view →
HNSC	DFS	Median	IV	0.382	0.264	.003	34	view →
SKCM	OS	Tertile	IV	0.787	0.166	.002	27	view →
UCEC	DFS	Median	All	0.800	0.875	.009	22	view →
LIHC	OS	Quartile	II,III,IV	0.340	0.690	.007	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

OSBPL6–UVM (DFS)

Open the UVM breakdown →