OSBPL6

Across TCGA patient cohorts, OSBPL6 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL6-associated genes across cancer lineages are Rad50, JNK_pT183_Y185, and Shc_pY317. Each is linked with OSBPL6 in more than 3 cancer types. Because this analysis shows association rather than direction, both OSBPL6-to-partner and partner-to-OSBPL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by OSBPL6-low versus OSBPL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL6→partner) and Y-score (partner→OSBPL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.168	-1.912	.012	.004	3	4
UCEC	JNK_pT183_Y185 →	-0.097	-1.222	.039	.032	3	3
UCEC	Shc_pY317 →	-0.116	-1.321	.006	.005	3	3
STAD	PDCD4 →	-0.509	-3.000	.026	.036	3	2
UCEC	eIF4E →	+0.191	+1.678	.001	<.001	3	2
UCEC	FoxM1 →	+0.199	+1.321	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Rad50 by OSBPL6 expression — UCEC

Explore this box plot interactively →