OSBPL6

Across TCGA cell cohorts, OSBPL6 mutation is significantly associated with the RNA expression of many other genes, with 435 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSBPL6-associated genes across cancer lineages are IL2, SEMG1, and GFRA4. Each is linked with OSBPL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBPL6-to-partner and partner-to-OSBPL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL2 grouped by OSBPL6-low versus OSBPL6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL6→partner) and Y-score (partner→OSBPL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL2 →	+0.662	+3.691	<.001	.002	3	2
LUNG_SCLC	SEMG1 →	+0.012	+3.584	<.001	.003	3	1
LUNG_SCLC	GFRA4 →	+0.213	+4.409	<.001	<.001	3	1
LUNG_SCLC	IL3 →	+0.035	+4.029	<.001	<.001	3	1
LUNG_SCLC	RPTN →	+0.006	+3.684	<.001	.001	3	1
LUNG_SCLC	PRAMEF33 →	+0.326	+4.029	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 435 associations by consensus.

IL2 by OSBPL6 expression — BLOOD_Leukemia

Explore this box plot interactively →