OSBPL6

Across TCGA cell cohorts, OSBPL6 mutation is significantly associated with the mutation status of many other genes, with 5,808 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSBPL6-associated genes across cancer lineages are ADAMTSL3, TRPC4, and CNTN4. Each is linked with OSBPL6 in more than 5 cancer types. Because this analysis shows association rather than direction, both OSBPL6-to-partner and partner-to-OSBPL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAMTSL3 grouped by OSBPL6-low versus OSBPL6-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL6→partner) and Y-score (partner→OSBPL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ADAMTSL3 →	+3.277	+3.954	.004	.004	1	6
LARGE_INTESTINE	TRPC4 →	+1.925	+2.000	.002	.002	1	5
LARGE_INTESTINE	CNTN4 →	+2.703	+3.479	<.001	<.001	1	5
LARGE_INTESTINE	GRIA1 →	+1.925	+2.000	.002	.002	1	5
CNS	PPP1R16B →	+5.277	+4.459	.005	.005	1	4
LARGE_INTESTINE	NF1 →	+2.063	+2.739	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,808 associations by consensus.

ADAMTSL3 by OSBPL6 expression — CNS

Explore this box plot interactively →