OSBPL5

Across TCGA pan-cancer cohorts, OSBPL5 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of OSBPL5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where OSBPL5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types OSBPL5 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and OV are the cancer types where OSBPL5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OSBPL5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.448	<.001	9	view →
LSCC	Male	II,III,IV	−0.192	<.001	5	view →
OV	All	All	−0.504	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

OSBPL5–COAD

Open the COAD breakdown →