OSBPL5

Across TCGA pan-cancer cohorts, OSBPL5 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated OSBPL5 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher OSBPL5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OSBPL5 expression acts as an unfavorable survival marker, although some lineages such as THYM and THCA show a favorable association.

LUAD, MESO, and LUSC are the cancer types where OSBPL5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.741	0.890	.001	78	view →
MESO	DFS	Tertile	All	0.238	0.421	.003	51	view →
LUSC	DFS	Tertile	All	0.363	0.507	.006	36	view →
ACC	DFS	Tertile	II,III,IV	0.162	0.709	.001	36	view →
KICH	DFS	Tertile	III,IV	0.332	1.000	.004	34	view →
THYM	OS	Median	All	1.000	0.729	<.001	25	view →
CESC	DFS	Quartile	All	0.602	0.820	.001	24	view →
HNSC	OS	Tertile	III,IV	0.552	0.874	.001	19	view →
COAD	DFS	Median	IV	0.267	0.682	.008	17	view →
BLCA	DFS	Quartile	All	0.272	0.670	.001	16	view →
THCA	DFS	Median	All	0.929	0.861	.003	16	view →
ESCA	OS	Tertile	II,III,IV	0.631	0.426	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

OSBPL5–LUAD (OS)

Open the LUAD breakdown →