OSBPL5

Across TCGA patient cohorts, OSBPL5 mutation is significantly associated with the RNA expression of many other genes, with 2,709 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL5-associated genes across cancer lineages are RNU1-49P, RNU6-290P, and RNA5SP419. Each is linked with OSBPL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both OSBPL5-to-partner and partner-to-OSBPL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-49P grouped by OSBPL5-low versus OSBPL5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL5→partner) and Y-score (partner→OSBPL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU1-49P →	+0.255	+3.993	<.001	.008	3	3
BRCA	RNU6-290P →	+0.402	+7.731	<.001	.009	3	3
UCEC	RNA5SP419 →	+0.410	+1.755	<.001	.001	3	3
CESC	PPP1R9A-AS1 →	+0.148	+4.133	<.001	.004	3	2
CESC	NF1P10 →	+0.139	+4.984	<.001	.003	3	2
BRCA	OR4A17P →	+0.029	+7.731	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,709 associations by consensus.

RNU1-49P by OSBPL5 expression — SKCM

Explore this box plot interactively →