OSBPL5

Across TCGA patient cohorts, OSBPL5 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL5-associated genes across cancer lineages are 4E-BP1, Di-Ras3, and DJ-1. Each is linked with OSBPL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBPL5-to-partner and partner-to-OSBPL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by OSBPL5-low versus OSBPL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL5→partner) and Y-score (partner→OSBPL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.277	+1.936	.001	.008	3	2
UCEC	Di-Ras3 →	-0.128	-1.222	.007	.035	3	2
UCEC	DJ-1 →	+0.129	+2.598	.017	.005	3	2
UCEC	EGFR_pY1068 →	-0.260	-1.716	.001	.003	3	1
UCEC	ERK2 →	+0.181	+2.169	.003	.003	3	1
UCEC	ACC1 →	+0.262	+1.362	.026	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

4E-BP1 by OSBPL5 expression — UCEC

Explore this box plot interactively →