OSBPL5

Across TCGA cell cohorts, OSBPL5 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OSBPL5-associated genes across cancer lineages are PPP1R2C, SIRPD, and GIMD1. Each is linked with OSBPL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both OSBPL5-to-partner and partner-to-OSBPL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R2C grouped by OSBPL5-low versus OSBPL5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL5→partner) and Y-score (partner→OSBPL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPP1R2C →	+0.115	+3.539	<.001	.002	3	3
LUNG_NSCLC_LUSC	SIRPD →	+0.037	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	GIMD1 →	+0.017	+4.584	<.001	.001	3	1
OVARY	KLHL40 →	+0.011	+4.450	<.001	.004	3	1
OVARY	PNLIPRP1 →	+0.039	+4.450	<.001	.004	3	1
OVARY	OR11H2 →	+0.073	+4.450	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

PPP1R2C by OSBPL5 expression — BLOOD_Leukemia

Explore this box plot interactively →