OSBPL3

Across TCGA cell cohorts, OSBPL3 mutation is significantly associated with the mutation status of many other genes, with 3,758 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSBPL3-associated genes across cancer lineages are CR2, ZHX2, and TRPM3. Each is linked with OSBPL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both OSBPL3-to-partner and partner-to-OSBPL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CR2 grouped by OSBPL3-low versus OSBPL3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL3→partner) and Y-score (partner→OSBPL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CR2 →	+5.095	+4.442	.001	.001	1	4
BREAST	ZHX2 →	+5.095	+4.442	.001	.001	1	4
SKIN	TRPM3 →	+2.641	+2.548	.008	.008	1	4
BLOOD_Lymphoma	DICER1 →	+3.554	+3.731	.003	.003	1	4
BLOOD_Leukemia	ZMIZ1 →	+3.101	+4.847	<.001	<.001	1	4
BLOOD_Leukemia	TOP2A →	+2.823	+3.665	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,758 associations by consensus.

CR2 by OSBPL3 expression — BREAST

Explore this box plot interactively →