OSBPL10

Across TCGA pan-cancer cohorts, OSBPL10 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated OSBPL10 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher OSBPL10 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OSBPL10 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

PDAC, GBM, and LSCC are the cancer types where OSBPL10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.702	0.943	.005	16	view →
GBM	DFS	Median	All	0.629	0.800	.013	10	view →
LSCC	OS	Median	II,III,IV	0.881	1.000	.016	9	view →
CCRCC	DFS	Median	All	0.590	0.831	.024	7	view →
LUAD	OS	Quartile	III,IV	0.819	0.353	.027	4	view →
UCEC	DFS	Median	All	0.784	0.934	.022	2	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

OSBPL10–PDAC (DFS)

Open the PDAC breakdown →