OSBPL10

Across TCGA pan-cancer cohorts, OSBPL10 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of OSBPL10’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where OSBPL10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OSBPL10 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

COAD, KICH, and BLCA are the cancer types where OSBPL10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OSBPL10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+0.907	<.001	11	view →
KICH	Male	III,IV	−1.859	<.001	9	view →
BLCA	Male	III,IV	−2.368	<.001	8	view →
THCA	Female	III,IV	+0.923	<.001	8	view →
HNSC	All	All	+0.442	<.001	8	view →
STAD	All	All	+0.788	<.001	7	view →
CHOL	Male	All	+1.716	<.001	5	view →
LUAD	All	All	+0.359	<.001	5	view →
KIRP	All	All	+0.643	.001	4	view →
LIHC	Female	All	+0.399	.007	3	view →
READ	Female	All	+0.630	.012	2	view →
LUSC	Female	All	−0.461	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

OSBPL10–COAD

Open the COAD breakdown →