OSBPL10

Across TCGA patient cohorts, OSBPL10 mutation is significantly associated with the RNA expression of many other genes, with 3,284 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL10-associated genes across cancer lineages are IGHD2-2, PARD6A, and EIF3I. Each is linked with OSBPL10 in more than 2 cancer types. Because this analysis shows association rather than direction, both OSBPL10-to-partner and partner-to-OSBPL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD2-2 grouped by OSBPL10-low versus OSBPL10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL10→partner) and Y-score (partner→OSBPL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD2-2 →	+0.876	+1.498	.001	.001	3	3
UCEC	PARD6A →	+0.839	+2.415	<.001	<.001	3	2
SKCM	EIF3I →	+0.363	+3.195	.005	.009	3	2
UCEC	GAK →	+0.255	+1.483	.003	.007	3	2
UCEC	VPS33B →	+0.235	+1.928	.003	<.001	3	2
UCEC	HDDC3 →	+0.335	+1.316	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,284 associations by consensus.

IGHD2-2 by OSBPL10 expression — UCEC

Explore this box plot interactively →