OSBP

Across TCGA cell cohorts, OSBP mutation is significantly associated with the RNA expression of many other genes, with 104 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSBP-associated genes across cancer lineages are PRSS58, MMP26, and OR51L1. Each is linked with OSBP in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBP-to-partner and partner-to-OSBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by OSBP-low versus OSBP-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBP→partner) and Y-score (partner→OSBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
LUNG_NSCLC_LUAD	MMP26 →	+0.231	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR51L1 →	+0.030	+4.662	.004	.005	3	1
LUNG_NSCLC_LUAD	NPAP1 →	+0.104	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	LCE1B →	+0.047	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR5H8 →	+0.014	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

PRSS58 by OSBP expression — PANCREAS

Explore this box plot interactively →