ORMDL3

Across TCGA patient cohorts, ORMDL3 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,977 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ORMDL3-associated proteins across cancer lineages are PIP4K2B, CDA, and NPEPPS. Each is linked with ORMDL3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ORMDL3-to-partner and partner-to-ORMDL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ORMDL3 versus PIP4K2B in BRCA, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ORMDL3→partner) and Y-score (partner→ORMDL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PIP4K2B →	+0.440	+1.044	<.001	<.001	3	6
GBM	CDA →	-0.864	-0.289	<.001	<.001	3	5
OV	NPEPPS →	+0.356	+0.474	<.001	<.001	3	4
BRCA	RHOT1 →	+0.282	+0.863	<.001	.001	3	4
HNSC	LTB4R_S320 →	-0.957	-0.865	<.001	.003	3	4
LUAD	FAF1_S582 →	-0.790	-0.870	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,977 associations by consensus.

ORMDL3 vs PIP4K2B — BRCA

Explore this scatter interactively →