ORMDL3

Across TCGA patient cohorts, ORMDL3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,766 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ORMDL3-associated genes across cancer lineages are RN7SL471P, STX1B, and RPS16. Each is linked with ORMDL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORMDL3-to-partner and partner-to-ORMDL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ORMDL3 versus RN7SL471P in HNSC, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORMDL3→partner) and Y-score (partner→ORMDL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL471P →	+4.129	+0.321	.001	.003	3	2
HNSC	STX1B →	-0.747	-0.346	.008	.009	3	2
LUAD	RPS16 →	-0.594	-0.214	<.001	.002	3	2
BRCA	RAB19 →	+0.773	+0.428	<.001	<.001	3	2
BRCA	KLHDC7A →	+1.910	+0.440	<.001	<.001	3	2
BRCA	VTI1B →	+0.329	+0.330	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,766 associations by consensus.

ORMDL3 vs RN7SL471P — HNSC

Explore this scatter interactively →