ORMDL3

Across TCGA patient cohorts, ORMDL3 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ORMDL3-associated genes across cancer lineages are Monocytes, Osteoblast, and iDC. Each is linked with ORMDL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORMDL3-to-partner and partner-to-ORMDL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by ORMDL3-low versus ORMDL3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORMDL3→partner) and Y-score (partner→ORMDL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Monocytes →	+0.072	+6.734	<.001	.018	3	1
STAD	Osteoblast →	+0.040	+3.669	<.001	.049	3	1
UCEC	iDC →	-0.180	-3.169	.049	.020	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Monocytes by ORMDL3 expression — COAD

Explore this box plot interactively →