ORMDL3

Across TCGA cell cohorts, ORMDL3 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ORMDL3-associated genes across cancer lineages are TBC1D21 and OR2V1. Each is linked with ORMDL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORMDL3-to-partner and partner-to-ORMDL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by ORMDL3-low versus ORMDL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORMDL3→partner) and Y-score (partner→ORMDL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR2V1 →	+0.034	+4.510	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

TBC1D21 by ORMDL3 expression — LARGE_INTESTINE

Explore this box plot interactively →