ORMDL3

Across TCGA cell cohorts, ORMDL3 mutation is significantly associated with the mutation status of many other genes, with 3,080 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ORMDL3-associated genes across cancer lineages are DNAAF1, TRIM11, and GABPA. Each is linked with ORMDL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORMDL3-to-partner and partner-to-ORMDL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAAF1 grouped by ORMDL3-low versus ORMDL3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORMDL3→partner) and Y-score (partner→ORMDL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DNAAF1 →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	TRIM11 →	+4.000	+5.050	.008	.008	1	2
BLOOD_Leukemia	GABPA →	+5.321	+5.894	.002	.002	1	2
BLOOD_Leukemia	CCDC174 →	+5.321	+5.894	.002	.002	1	2
BLOOD_Leukemia	USP43 →	+4.736	+5.560	.003	.003	1	2
BLOOD_Leukemia	ACSS1 →	+4.321	+5.285	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,080 associations by consensus.

DNAAF1 by ORMDL3 expression — BLOOD_Leukemia

Explore this box plot interactively →