ORC6

Across TCGA patient cohorts, ORC6 mutation is significantly associated with the RNA expression of many other genes, with 841 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORC6-associated genes across cancer lineages are MIR548A3, MIR3661, and RPS7P13. Each is linked with ORC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC6-to-partner and partner-to-ORC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548A3 grouped by ORC6-low versus ORC6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC6→partner) and Y-score (partner→ORC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR548A3 →	+0.493	+4.411	<.001	<.001	3	2
UCEC	MIR3661 →	+0.784	+2.436	<.001	.002	3	2
HNSC	RPS7P13 →	+0.113	+5.578	<.001	.004	3	2
UCEC	RN7SL97P →	+0.139	+2.713	<.001	.002	3	2
CESC	RN7SL122P →	+0.072	+4.144	<.001	.009	3	2
BRCA	RN7SL457P →	+0.153	+5.610	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 841 associations by consensus.

MIR548A3 by ORC6 expression — CESC

Explore this box plot interactively →